Is this all right?Scientists use stem cells to help them quit drinking

2022-07-23 0 By

No wine is not a gift, no wine is not a banquet.But let’s be clear: Is moderate drinking good for your health?The answer is no.Results from a large 2018 analysis of 28 million people showed that even so-called moderate drinking (20 grams of pure alcohol per day) increased the risk of death by 7% [1].Furthermore, scientists have confirmed that alcohol can cause permanent damage to human DNA and increase the risk of cancer [2].But if you’re really…I have to, so please don’t become dependent on alcohol, don’t binge drink.Because it’s all a disease: Alcohol use disorder (AUD).At present, the types of intervention drugs for alcohol use disorder are limited, and patients’ compliance is not high.But a Chilean scientist came up with a familiar one: mesenchymal stem cells.Mesenchymal stem cells again?Everyone knows that drinking is bad for the body, especially the liver.In the research progress of alcoholic fatty liver and alcoholic cirrhosis, mesenchymal stem cells (MSC) are not rare.MSC treatment of alcohol use disorders is not well documented.The main ones are mostly about one scientist, Yedy Israel, a professor at the University of Chile, whose research focuses on the treatment of alcoholism.Several studies, including director of gene Therapy Group at The University of Chile and President of the American Society on Alcoholism, have shown that long-term alcohol consumption leads to an increase in inflammatory factors in the gut [3] and brain [4.5].In the brain, alcohol-induced neuroinflammation activates astrocytes and microglias, inducing secretion of pro-inflammatory cytokines and neurodegeneration [6].At the same time, the pro-inflammatory state also increased the alcohol consumption of experimental animals and humans [7.8].Studies have shown that peripheral inflammation levels recover rapidly after cessation of alcohol consumption, but brain inflammation levels persist, which may be related to the lack of regulatory T cells in the brain [9.10].This high level of inflammation in the brain, in turn, was significantly associated with an increased risk of relapse after abstaining [7.8].So Here’s Dr. Israel’s approach: anti-inflammatory.Mesenchymal stem cells: “I know this…”MSCS are known for their anti-inflammatory effects and are used in the treatment of a variety of immune diseases.Among the 10 mesenchymal stem cell drugs currently on the market worldwide, 7 use its immunomodulatory function.It’s not surprising that Israel thinks about MSC.02Israel’s Research 02Israel has conducted a number of studies around MSCS.First, he wanted to see how the “most direct” method — MSC — worked when injected into the rat brain.The researchers chose a strain of rats with a preference for alcohol and gave them a buffet of 10 proof alcohol, 20 proof alcohol and drinking water.At the beginning of the experiment, the rats were treated with MSC and control after alcohol addiction.The researchers went on to observe how MSCS affect “long-term alcohol consumption” in rats.To observe the effects of MSC on abstinence, the researchers gave rats a free drinking session followed by two weeks of alcohol withdrawal and a 60-minute drinking session to see how MSC affected “relapse drinking.”As a result, Israel found that a single intraventricular infusion of MSC reduced “long-term alcohol consumption” in rats by 50%, lasting for 10 days to the end of the study.At the same time, there was an 80-85% reduction in “recurrent drinking” that lasted 40 days until the end of the study [11].In the second trial, Israel chose to activate MSC and enhance anti-inflammatory factor expression levels.The results showed a 70% reduction in “long-term drinking” and an 80% reduction in “recurrent drinking” [12].Increased expression of glial acidic fibrin (GFAP) expressed by astrocytes is a marker of neuroinflammation. Long-term alcohol intake increases GFAP by 60-80%, but this effect can be completely eliminated by MSCS.But injecting cells into the ventricle in order to stop drinking is, in fact, “insane.” So Israel tried two more “realistic billion point” procedures:Intravenous infusion of 3D cultured MSC spheres [13] INTRANasally administered MSC exosomes [14] significantly more MSC spheres were injected into the rat brain. MSC spheres cultured under 3D conditions showed significantly improved anti-inflammatory ability and reduced cell volume by 90%, so they could enter the brain after intravenous administration.A single infusion of MSC spheres inhibited “long-term drinking” and “recurrent drinking” by 80-90% and was significantly maintained over 3-5 weeks.MSC exosomes, on the other hand, provide a non-invasive delivery method that is more suitable for the treatment of chronic diseases.Moreover, Israel gradually added nicotine to his “withdrawal targets” [15.16].Using activated MSC exosomes, intranasally administered, the researchers inhibited 85% of long-term alcohol intake and 75% of long-term nicotine intake, respectively, as well as 85-90% of “recurrent intake.”Smoking cessation and alcohol abstinence, MSC and addiction disease have a long history.What to look forward to?Israel believes MSC may be an effective new treatment for alcohol use disorders, but his study was limited to rats. Do we have human clinical trials?Yes, a Phase I/II, prospective, randomized, double-blind, placebo-controlled trial is underway with high design standards.The indication for the study is alcohol use disorder in combination with major depression. It is funded by the National Institute on Alcohol Abuse and Alcoholism and led by Dr. Dante Durand of the University of Miami, and is expected to be completed by 2025.If the 80-person clinical trial results in positive results, it may open a new door for people with alcohol use disorder to return to healthy lives.MSC has the potential to treat both alcoholic fatty liver disease, alcoholic cirrhosis, and alcohol use disorder, eliminating the high levels of inflammation associated with alcohol.For wine lovers, mesenchymal stem cells can be useful…- End –